成昱

教授 博士生导师

国家青年千人(2015年)

同济大学 医学院 生物医学工程与纳米科学研究院

地址:上海赤峰路67号 200092

联系电话:021-65983706-215(Office)

Email: yucheng@tongji.edu.cn

教育经历

20062011年: 美国凯斯西储大学,物理化学,博士学位

20042006年: 武汉大学 化学与分子科学学院,有机化学 ,硕士学位

20002004年: 武汉大学 化学与分子科学学院,应用化学 ,学士学位

工作经历

2014年~ 教授, 同济大学

2011-2014年 博士后,美国芝加哥大学医学院脑癌研究中心

荣誉与获奖

2014 Chicago Biomedical Consortium Postdoctoral Research Award

2014 The University of Chicago 21st Annual Charles B. Huggins Symposium, 学术口头报告奖

2012 The University of Chicago Biological Sciences Division Postdoc Association, Travel Award

2010 239th National American Chemical Society Meeting, 最佳学生口头报告奖和优秀学术海报奖

2010 American Chemical Society Meeting-in-Miniature, Graduate Student Awardee

2010 Research ShowCASE Graduate Student Poster Contest, Case Western Reserve University, 学术海报二等奖

2009 The Microscopy Society of Northeastern Ohio Fall Meeting, 学术海报一等奖

2008-2009 Research ShowCASE Graduate Student Poster Contest, Case Western Reserve University, 学术海报一等奖

2007 Research ShowCASE Graduate Student Poster Contest, Case Western Reserve University, 学术海报荣誉奖

2004年 湖北省优秀本科生论文奖

20012003年 武汉大学优秀学生

主要学术及社会兼职

Advanced Materials, Advanced Functional Materials, Chemical Communications, Journal of Controlled Release, Journal of Materials Chemistry B, Current Medical Chemistry, Integrative Biology, Analyst, Langmuir, Pharmaceutical Research, Nanotechnology, Metallomics, International Journal of Nanomedicine, Anti-Cancer Agents in Medicinal Chemistry, Laser in Surgery and Medicine, New Journal of Chemistry, Photodiagnosis and Photodynamic Therapy, Biomedical Materials, Analytical Method, Advanced Healthcare Materials, Biomaterials Science, RSC Advances, Cancer Management and Research, and International Journal of Medicinal Chemistry等学术期刊评审人

研究领域

研究包括: 纳米智能材料在脑肿瘤诊断及治疗中的应用、纳米材料与干细胞联用在癌症治疗中的应用以及纳米材料生物相容性的研究。在Advanced Drug Delivery Reviews (影响因子15.431) Journal of American Chemical Society (影响因子10.677)Small(影响因子7.823)Biomaterials(影响因子7.604)等国际高水平杂志上发表SCI论文及著作共17篇。创新成果被国际同行广泛认可,单篇他引次数已经超过250次。包括雅虎、C&ENScience Daily等在内的国内外知名媒体对相关研究成果进行了详细报道。作为项目负责人,独立承担美国Chicago Biomedical Consortium Postdoctoral Research Grant,并多次获得国际学术会议优秀报告奖励。目前担任包括Advanced Materials Advanced Functional MaterialsChemical CommunicationsJournal of Controlled Release20多个国际知名学术期刊的评审人。

研究方向

1. 生物医用纳米材料在肿瘤治疗中的应用;

2. 干细胞相关纳米生物界面;

3. 纳米材料为载体的光动力治疗抗癌药物新型靶向给药系统;

4. 生物医用纳米体系在细胞水平与动物中的作用机理,药物释放机理及生物相容性的研究。

代表性文章

Yu Cheng, Anna C. Samia, Joseph D. Meyers, Irene Panagopoulos, Baowei Fei, Clemens Burda “Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer” J. Am. Chem. Soc. 2008, 130, 10643. (Highlighted by Sciencedaily and Yahoo, citation > 250, IF:10.677)

Yu Cheng, Anna C. Samia, Jun Li, Malcolm E. Kenney, Andrew Resnick, Clemens Burda. “Delivery and Efficacy of a Cancer Drug as Function of the Bond to the Gold Nanoparticle Surface”, Langmuir 2010, 26, 2248 (Cover and Invited Feature Article, citation: >60, IF: 4.187).

Yu Cheng, Clemens Burda “Nanoparticle-based Photodynamic Therapy”, Book Chapter of Comprehensive Nanoscience and Technology, 2010, Elsevier.

Tennyson L. Doane, Yu Cheng, Amir Babar, Reghan J. Hill, Clemens Burda “Electrophoretic Mobilities of PEGylated Gold NPs”, J. Am. Chem. Soc. 2010, 132, 15624. (IF:10.677)

Yu Cheng, Joseph D. Meyers, Ann-Marie Broome, Malcolm E. Kenney, James P. Basilion, Clemens Burda “Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates”, J. Am. Chem. Soc. 2011, 133, 2583. (Citation: >50, IF:10.677)

Yu Cheng, Joseph D. Meyers, Ann-Marie Broome, Tennyson L. Doane, Malcolm E. Kenney, Clemens Burda, James P. Basilion “Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?”, Small, 2011, 7, 2301. (IF: 7.823)

Yu Cheng, Ramin Morshed , Shih-Hsun Cheng, Alex Tobias, Brenda Auffinger, Derek A. Wainwright, Lingjiao Zhang, Catherine Yunis, Yu Han, Chin-Tu Chen, Leu-Wei Lo, Karen S. Aboody, Atique U. Ahmed, Maciej S. Lesniak. “Nanoparticle-Programmed Self-Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy”, Small, 2013, 9, 4123. (Highlighted by C&EN, IF: 7.823)

Ramin Morshed, Yu Cheng, Brenda Auffinger, Michelle Wegscheid, Maciej Lesniak. “The potential of polymeric micelles in the context of glioblastoma multiforme therapy”, Frontiers of Pharmacology, 2013, 4, 157.

Yu Cheng, Ramin Morshed, Brenda Auffinger, Alex Tobias, Maciej S. Lesniak. “Multifunctional Nanoparticles for Brain Tumor Diagnosis and Therapy”, Adv. Drug Deliv. Rev. 2014, 66, 42. (IF: 15.431)

Yu Cheng, Tennyson L. Doane, Chi-Hung Chuang, Assem Ziady, Clemens Burda,“Near Infrared Light-Triggered Generation and Release of a Photodynamic Therapy Drug from Gold Nanoparticle Carriers”, Small, 2014, 10, 1799.(IF: 7.823)

Eun Ji Chung, Yu Cheng (共同第一作者), Ramin Morshed, Kathryn Nord, Yu Han, Michelle Wegscheid, Brenda Auffinger, Derek A. Wainwright, Maciej S. Lesniak, Matthew V. Tirrell. “Fibrin-Binding, Peptide Amphiphile Micelles for Targeting Glioblastoma”, Biomaterials, 2014, 35, 1249. (IF: 7.604)

Yu Cheng, Qing Dai, Ramin Morshed, Xiaobing Fan, Michelle L. Wegscheid, Derek A. Wainwright, Yu Han, Lingjiao Zhang, Brenda Auffinger, Alex L. Tobias, Esther Rincón, Bart Thaci, Atique U. Ahmed, Peter Warnke, Chuan He, Maciej S. Lesniak, “Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging”, Small, 2014, accepted. (IF: 7.823)

Yingjie Fu, Qishuai Feng, Yifan Chen, Yajing Shen, Qihang Su, Yinglei Zhang, Xiang Zhou, and Yu Cheng, “Comparison of Two Approaches for the Attachment of a Drug to Gold Nanoparticles and Their Anticancer Activities”, Mol Pharmaceut. 2016, 13, 9. (IF: 4.556)

Yajing Shen, Congyu Wu, Taro Q. P. Uyeda, Gustavo R. Plaza, Bin Liu, Yu Han, Maciej S. Lesniak, and Yu Cheng, “Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field”, Theranostics, 2017, 7, 6. (IF: 8.854)

Qishuai Feng, Yajing Shen, Yingjie Fu, Megan E. Muroski, Peng Zhang, Qiaoyue Wang, Chang Xu, Maciej S. Lesniak, Gang Li, and Yu Cheng, “Self-Assembly of Gold Nanoparticles Shows Microenvironment-Mediated Dynamic Switching and Enhanced Brain Tumor Targeting”, Theranostics, 2017, 7, 7. (IF: 8.854)

Yingjie Fu, Qishuai Feng, Yajing Shen, Mengwei Chen, Chang Xu, Yu Cheng, Xiang Zhou, “A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers”, Rsc Adv. 2018, 8, 11. (IF: 2.94)

Chang Xu, Qishuai Feng, Haocheng Yang, Guangxue Wang, Liqun Huang, Qianwen Bai, Chuyi Zhang, Yilong Wang, Yingna Chen, Qian Cheng, Mengwei Chen, Yu Han, Zuoren Yu, Maciej S. Lesniak, Yu Cheng, “A Light‐Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo‐Photothermal Therapy of Triple Negative Breast Cancer”, Adv Sci. 2018, 5, 10. (IF: 12.441)

Peng Xu, Qishuai Feng, Xiran Yang, Simin Liu, Chang Xu, Liqun Huang, Mengwei Chen, Feng Liang, and Yu Cheng, “Near Infrared Light Triggered Cucurbit[7]uril-Stabilized Gold Nanostars as a Supramolecular Nanoplatform for Combination Treatment of Cancer”, Bioconjugate Chem. 2018, 29, 8. (IF: 4.48)

Congyu Wu, Yajing Shen, Mengwei Chen, Kun Wang, Yongyong Li, Yu Cheng, “Recent Advances in Magnetic‐Nanomaterial‐Based Mechanotransduction for Cell Fate Regulation”, Advanced Materials, 2018, 30(17): 1705673. (IF: 21.95)

Liqun Huang, Chang Xu, Peng Xu, Yu Qin, Mengwei Chen, Qishuai Feng, Jing Pan, Qian Cheng, Feng Liang, Xiaofei Wen, Ying Wang, Yufang Shi, and Yu Cheng, “Intelligent Photosensitive Mesenchymal Stem Cells and Cell-Derived Microvesicles for Photothermal Therapy of Prostate Cancer”, Nanotheranostics 2018, 3, 1.

Congyu Wu, Megan E.Muroski, Jason Miska, Catalina Lee-Chang, Yajing Shen, Aida Rashidi, Peng Zhang, Ting Xiao, Yu Han, Aurora Lopez-Rosas, Yu Cheng, Maciej S.Lesniak, “Repolarization of myeloid derived suppressor cells via magnetic nanoparticles to promote radiotherapy for glioma treatment”, Nanomedicine. 2019, 16, 126. (IF: 6.5)

主持项目

1.      项目名称:神经干细胞介导的纳米磁力刀靶向作用于脑胶质瘤的实验研究

国家自然科学基金面上项目,66.6万,2016-2019

2.      项目名称:引进人才科研启动经费

中组部青年千人计划,300万,2015-2017

3.      项目名称:靶向线粒体的纳米磁力刀在脑肿瘤治疗中的应用研究

上海市科委国际合作项目, 30万,2016-2019

4.      项目名称:癌症精准医疗微纳机器人前沿基础研究

上海市教育委员会科研创新计划项目,300万,2017.07-2022

5.      项目名称:磁力调控内涵体/溶酶体逃逸的纳米载药系统抗胶质瘤作用

国家自然科学基金委员会资助项目,59万,2019.01-2022.12